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1.

The antigenic anatomy of SARS-CoV-2 receptor binding domain.

Dejnirattisai, Wanwisa; Zhou, Daming; Ginn, Helen M; Duyvesteyn, Helen M E; Supasa, Piyada; Case, James Brett; Zhao, Yuguang; Walter, Thomas S; Mentzer, Alexander J; Liu, Chang; Wang, Beibei; Paesen, Guido C; Slon-Campos, Jose; López-Camacho, César; Kafai, Natasha M; Bailey, Adam L; Chen, Rita E; Ying, Baoling; Thompson, Craig; Bolton, Jai; Fyfe, Alex; Gupta, Sunetra; Tan, Tiong Kit; Gilbert-Jaramillo, Javier; James, William; Knight, Michael; Carroll, Miles W; Skelly, Donal; Dold, Christina; Peng, Yanchun; Levin, Robert; Dong, Tao; Pollard, Andrew J; Knight, Julian C; Klenerman, Paul; Temperton, Nigel; Hall, David R; Williams, Mark A; Paterson, Neil G; Bertram, Felicity K R; Siebert, C Alistair; Clare, Daniel K; Howe, Andrew; Radecke, Julika; Song, Yun; Townsend, Alain R; Huang, Kuan-Ying A; Fry, Elizabeth E; Mongkolsapaya, Juthathip; Diamond, Michael S.

Cell ; 184(8): 2183-2200.e22, 2021 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-33756110

2.

An immunodominant NP_105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.

Peng, Yanchun; Felce, Suet Ling; Dong, Danning; Penkava, Frank; Mentzer, Alexander J; Yao, Xuan; Liu, Guihai; Yin, Zixi; Chen, Ji-Li; Lu, Yongxu; Wellington, Dannielle; Wing, Peter A C; Dominey-Foy, Delaney C C; Jin, Chen; Wang, Wenbo; Hamid, Megat Abd; Fernandes, Ricardo A; Wang, Beibei; Fries, Anastasia; Zhuang, Xiaodong; Ashley, Neil; Rostron, Timothy; Waugh, Craig; Sopp, Paul; Hublitz, Philip; Beveridge, Ryan; Tan, Tiong Kit; Dold, Christina; Kwok, Andrew J; Rich-Griffin, Charlotte; Dejnirattisa, Wanwisa; Liu, Chang; Kurupati, Prathiba; Nassiri, Isar; Watson, Robert A; Tong, Orion; Taylor, Chelsea A; Kumar Sharma, Piyush; Sun, Bo; Curion, Fabiola; Revale, Santiago; Garner, Lucy C; Jansen, Kathrin; Ferreira, Ricardo C; Attar, Moustafa; Fry, Jeremy W; Russell, Rebecca A; Stauss, Hans J; James, William; Townsend, Alain.

Nat Immunol ; 23(1): 50-61, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34853448

3.

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.

Saphire, Erica Ollmann; Schendel, Sharon L; Fusco, Marnie L; Gangavarapu, Karthik; Gunn, Bronwyn M; Wec, Anna Z; Halfmann, Peter J; Brannan, Jennifer M; Herbert, Andrew S; Qiu, Xiangguo; Wagh, Kshitij; He, Shihua; Giorgi, Elena E; Theiler, James; Pommert, Kathleen B J; Krause, Tyler B; Turner, Hannah L; Murin, Charles D; Pallesen, Jesper; Davidson, Edgar; Ahmed, Rafi; Aman, M Javad; Bukreyev, Alexander; Burton, Dennis R; Crowe, James E; Davis, Carl W; Georgiou, George; Krammer, Florian; Kyratsous, Christos A; Lai, Jonathan R; Nykiforuk, Cory; Pauly, Michael H; Rijal, Pramila; Takada, Ayato; Townsend, Alain R; Volchkov, Viktor; Walker, Laura M; Wang, Cheng-I; Zeitlin, Larry; Doranz, Benjamin J; Ward, Andrew B; Korber, Bette; Kobinger, Gary P; Andersen, Kristian G; Kawaoka, Yoshihiro; Alter, Galit; Chandran, Kartik; Dye, John M.

Cell ; 174(4): 938-952.e13, 2018 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-30096313

4.

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.

MacLean, Andrew J; Richmond, Niamh; Koneva, Lada; Attar, Moustafa; Medina, Cesar A P; Thornton, Emily E; Gomes, Ariane Cruz; El-Turabi, Aadil; Bachmann, Martin F; Rijal, Pramila; Tan, Tiong Kit; Townsend, Alain; Sansom, Stephen N; Bannard, Oliver; Arnon, Tal I.

Immunity ; 55(4): 718-733.e8, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35349789

5.

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang, Qiannan; Rigby, Rachel E; Young, George R; Hvidt, Astrid Korning; Davis, Tanja; Tan, Tiong Kit; Bridgeman, Anne; Townsend, Alain R; Kassiotis, George; Rehwinkel, Jan.

Immunity ; 54(9): 1961-1975.e5, 2021 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-34525337

6.

Vincenzo Cerundolo 1959-2020.

Townsend, Alain.

Nat Immunol ; 21(3): 243, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32015541

7.

Antigenic Characterization of Human Monoclonal Antibodies for Therapeutic Use against H7N9 Avian Influenza Virus.

Chang, Pengxiang; Lukosaityte, Deimante; Sealy, Joshua E; Rijal, Pramila; Sadeyen, Jean-Remy; Bhat, Sushant; Crossley, Sylvia; Daines, Rebecca; Huang, Kuan-Yin A; Townsend, Alain R; Iqbal, Munir.

J Virol ; 97(1): e0143122, 2023 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-36541801

8.

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8+ T Cells in the Face of Pre-Existing Humoral Immunity.

Zheng, Ming Z M; Fritzlar, Svenja; Wang, Zhongfang; Tan, Tiong Kit; Kedzierska, Katherine; Townsend, Alain; Reading, Patrick C; Wakim, Linda M.

J Immunol ; 209(10): 1832-1836, 2022 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-36426954

9.

Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.

Holzer, Barbara; Rijal, Pramila; McNee, Adam; Paudyal, Basudev; Martini, Veronica; Clark, Becky; Manjegowda, Tanuja; Salguero, Francisco J; Bessell, Emily; Schwartz, John C; Moffat, Katy; Pedrera, Miriam; Graham, Simon P; Noble, Alistair; Placido, Marie Bonnet-Di; La Ragione, Roberto M; Mwangi, William; Beverley, Peter; McCauley, John W; Daniels, Rodney S; Hammond, John A; Townsend, Alain R; Tchilian, Elma.

PLoS Pathog ; 17(8): e1009815, 2021 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-34347851

10.

Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans.

Huang, Kuan-Ying A; Tan, Tiong Kit; Chen, Ting-Hua; Huang, Chung-Guei; Harvey, Ruth; Hussain, Saira; Chen, Cheng-Pin; Harding, Adam; Gilbert-Jaramillo, Javier; Liu, Xu; Knight, Michael; Schimanski, Lisa; Shih, Shin-Ru; Lin, Yi-Chun; Cheng, Chien-Yu; Cheng, Shu-Hsing; Huang, Yhu-Chering; Lin, Tzou-Yien; Jan, Jia-Tsrong; Ma, Che; James, William; Daniels, Rodney S; McCauley, John W; Rijal, Pramila; Townsend, Alain R.

PLoS Pathog ; 17(12): e1010148, 2021 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-34890427

11.

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.

Holzer, Barbara; Rijal, Pramila; McNee, Adam; Paudyal, Basudev; Martini, Veronica; Clark, Becky; Manjegowda, Tanuja; Salguero, Francisco J; Bessell, Emily; Schwartz, John C; Moffat, Katy; Pedrera, Miriam; Graham, Simon P; Noble, Alistair; Bonnet-Di Placido, Marie; La Ragione, Roberto M; Mwangi, William; Beverley, Peter; McCauley, John W; Daniels, Rodney S; Hammond, John A; Townsend, Alain R; Tchilian, Elma.

PLoS Pathog ; 17(3): e1009330, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33662023

12.

Breadth and function of antibody response to acute SARS-CoV-2 infection in humans.

Huang, Kuan-Ying A; Tan, Tiong Kit; Chen, Ting-Hua; Huang, Chung-Guei; Harvey, Ruth; Hussain, Saira; Chen, Cheng-Pin; Harding, Adam; Gilbert-Jaramillo, Javier; Liu, Xu; Knight, Michael; Schimanski, Lisa; Shih, Shin-Ru; Lin, Yi-Chun; Cheng, Chien-Yu; Cheng, Shu-Hsing; Huang, Yhu-Chering; Lin, Tzou-Yien; Jan, Jia-Tsrong; Ma, Che; James, William; Daniels, Rodney S; McCauley, John W; Rijal, Pramila; Townsend, Alain R.

PLoS Pathog ; 17(2): e1009352, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33635919

13.

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.

Chauveau, Lise; Bridgeman, Anne; Tan, Tiong K; Beveridge, Ryan; Frost, Joe N; Rijal, Pramila; Pedroza-Pacheco, Isabela; Partridge, Thomas; Gilbert-Jaramillo, Javier; Knight, Michael L; Liu, Xu; Russell, Rebecca A; Borrow, Persephone; Drakesmith, Hal; Townsend, Alain R; Rehwinkel, Jan.

EMBO Rep ; 22(8): e52447, 2021 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-34142428

14.

Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs.

Martini, Veronica; Paudyal, Basu; Chrun, Tiphany; McNee, Adam; Edmans, Matthew; Atangana Maze, Emmanuel; Clark, Beckie; Nunez, Alejandro; Dolton, Garry; Sewell, Andrew; Beverley, Peter; MacLoughlin, Ronan; Townsend, Alain; Tchilian, Elma.

J Immunol ; 206(3): 652-663, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33328212

15.

Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka.

Jeewandara, Chandima; Guruge, Dinuka; Pushpakumara, Pradeep Darshana; Kamaladasa, Achala; Aberathna, Inoka Sepali; Ramu, Shyrar Tanussiya; Gunasekera, Banuri; Wijesinghe, Ayesha; Dissanayake, Osanda; Kuruppu, Heshan; Ranasinghe, Thushali; Jayathilaka, Deshni; Dayarathna, Shashika; Ekanayake, Dinithi; Jayamali, Jeewantha; Gamalath, Nayanathara; Mudunkotiwa, Anushika; Somathilake, Gayasha; Dissanayake, Madhushika; Harvie, Michael; Nimasha, Thashmi; Madusanka, Deshan; Jayadas, Tibutius; Wijayamuni, Ruwan; Schimanski, Lisa; Rijal, Pramila; Tan, Tiong K; Townsend, Alain; Ogg, Graham S; Malavige, Gathsaurie Neelika.

J Immunol ; 207(11): 2681-2687, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34750205

16.

Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma.

Nguyen, Dung; Xiao, Julie; Simmonds, Peter; Lamikanra, Abigail; Odon, Valerie; Ratcliff, Jeremy; Townsend, Alain; Roberts, David J; Harvala, Heli.

J Infect Dis ; 225(6): 971-976, 2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-34751775

17.

Immune responses to Sinopharm/BBIBP-CorV in individuals in Sri Lanka.

Jeewandara, Chandima; Aberathna, Inoka Sepali; Pushpakumara, Pradeep Darshana; Kamaladasa, Achala; Guruge, Dinuka; Wijesinghe, Ayesha; Gunasekera, Banuri; Tanussiya, Shyrar; Kuruppu, Heshan; Ranasinghe, Thushali; Dayarathne, Shashika; Dissanayake, Osanda; Gamalath, Nayanathara; Ekanayake, Dinithi; Jayamali, Jeewantha; Jayathilaka, Deshni; Dissanayake, Madushika; Madusanka, Deshan; Jayadas, Tibutius Thanesh; Mudunkotuwa, Anushika; Somathilake, Gayasha; Harvie, Michael; Nimasha, Thashmi; Danasekara, Saubhagya; Wijayamuni, Ruwan; Schimanski, Lisa; Rijal, Pramila; Tan, Tiong K; Dong, Tao; Townsend, Alain; Ogg, Graham S; Malavige, Gathsaurie Neelika.

Immunology ; 167(2): 275-285, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-35758860

18.

Comparison of the immunogenicity of five COVID-19 vaccines in Sri Lanka.

Jeewandara, Chandima; Aberathna, Inoka Sepali; Danasekara, Saubhagya; Gomes, Laksiri; Fernando, Suranga; Guruge, Dinuka; Ranasinghe, Thushali; Gunasekera, Banuri; Kamaladasa, Achala; Kuruppu, Heshan; Somathilake, Gayasha; Jayamali, Jeewantha; Jayathilaka, Deshni; Wijayatilake, Helanka Dinesh Kumara; Pushpakumara, Pradeep Darshana; Harvie, Michael; Nimasha, Thashmi; de Silva, Shiromi Devika Grace; Wijayamuni, Ruwan; Schimanski, Lisa; Rijal, Pramila; Tan, Jack; Townsend, Alain; Ogg, Graham S; Malavige, Gathsaurie Neelika.

Immunology ; 167(2): 263-274, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-35751563

19.

Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222.

Jayathilaka, Deshni; Jeewandara, Chandima; Gomes, Laksiri; Jayadas, Tibutius Thanesh Pramanayagam; Kamaladasa, Achala; Somathilake, Gayasha; Guruge, Dinuka; Pushpakumara, Pradeep Darshana; Ranasinghe, Thushali; Aberathna, Inoka Sepali; Danasekara, Saubhagya; Gunathilaka, Buddini; Kuruppu, Heshan; Wijewickrama, Ananda; Wijayamuni, Ruwan; Schimanski, Lisa; Tan, T K; Ogg, Graham S; Townsend, Alain; Malavige, Gathsaurie Neelika.

Clin Exp Immunol ; 208(3): 323-331, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35641142

20.

Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms.

McNee, Adam; Smith, Trevor R F; Holzer, Barbara; Clark, Becky; Bessell, Emily; Guibinga, Ghiabe; Brown, Heather; Schultheis, Katherine; Fisher, Paul; Ramos, Stephanie; Nunez, Alejandro; Bernard, Matthieu; Graham, Simon; Martini, Veronica; Chrun, Tiphany; Xiao, Yongli; Kash, John C; Taubenberger, Jeffery K; Elliott, Sarah; Patel, Ami; Beverley, Peter; Rijal, Pramila; Weiner, David B; Townsend, Alain; Broderick, Kate E; Tchilian, Elma.

J Immunol ; 205(3): 648-660, 2020 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-32591390

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